NPW terminal maturation
Gene co-expression module in Enteroendocrine cells
| Category | n cell program |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 16 genes have a known function matching the annotation |
Why this annotation
The hub gene NPW and the strongest-localized genes CEACAM5 and ENSG00000267881 (~11x) peak in N cells, with secondary enrichment in INSL5 and I cells, together with epithelial maturation genes (CEACAM5, S100A14, TMEM54, PPARG, PRR15). Because these genes are localized rather than spread, they mark a genuine late, terminally differentiated N/L/I state rather than contamination.
Genes
Most correlated modules
- Secretin/epithelial co-program · correlation 0.87
- Villus enterocyte-like state · correlation 0.80
- Neurotensin N-cell Program · correlation 0.80
- INSL5/N-cell epithelial state · correlation 0.79
- Small-intestinal absorptive signature · correlation 0.74
- RARRES1/PCSK5 small-bowel program · correlation 0.74
- Surface hypoxic state · correlation 0.72
- BMP/SMAD target genes · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.