RARRES1/PCSK5 small-bowel program
Gene co-expression module in Enteroendocrine cells
| Category | EEC development |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 8 genes have a known function matching the annotation |
Why this annotation
All eight core genes are enriched together in the small-intestinal hormone subsets (N, I, K cells) and absent from colonic EEC types, led by small-bowel epithelial genes RARRES1, LGALS2, ANKRD40CL and PCSK5. It is distinguished from the CDX2/HNF4G intestinal identity module by lacking intestinal transcription factors and by its RARRES1/LGALS2/PCSK5 content.
Genes
Most correlated modules
- Small-intestinal absorptive signature · correlation 0.91
- Small-intestinal I/K-cell signature · correlation 0.90
- CDX2/HNF4G intestinal identity · correlation 0.88
- Neurotensin N-cell Program · correlation 0.83
- Villus enterocyte-like state · correlation 0.80
- Small-intestinal Nutrient Sensing · correlation 0.78
- NPW terminal maturation · correlation 0.74
- Small-intestinal lipid metabolism · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.