Goblet-like secretory progenitor
Gene co-expression module in Enteroendocrine cells
| Category | EEC development |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 10 genes have a known function matching the annotation |
Why this annotation
The hub genes TFF3 and FCGBP, with NTN4, are goblet/Paneth secretory genes that peak in pre_EEC cells (TFF3 in 84% of them) rather than spreading evenly. This fits a residual goblet-like program in early EEC progenitors, but enrichment stays below 3x, so goblet ambient contamination remains a plausible alternative.
Genes
Most correlated modules
- Villus EC subpopulation · correlation 0.72
- Proximal regional identity · correlation 0.70
- SCN3A/HCN1 EC excitability · correlation 0.70
- RASGRP1/MME K-cell signaling · correlation 0.55
- LMX1B/OR51E1 EC-primed precursor · correlation 0.48
- Rho-GEF cytoskeletal signaling · correlation 0.47
- FGFRL1/VWC2 pre-EEC state · correlation 0.45
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.