Rho-GEF cytoskeletal signaling
Gene co-expression module in Enteroendocrine cells
| Category | migration & adhesion |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 9 genes have a known function matching the annotation |
Why this annotation
The Rac/Rho GEFs DOCK5 and PLEKHG1, the actin linker ABLIM1, the Slit receptor ROBO1 and the scramblase ANO6 suggest cytoskeletal remodelling and guidance signalling spread across EEC subsets. Its many long genes (FOXP2, RANBP17, SLC22A23) leave a long-gene capture axis as an equally plausible explanation, and the neighbourhood does not resolve this.
Genes
Most correlated modules
- CDX2/HNF4G intestinal identity · correlation 0.73
- Proximal MX/I-cell signature · correlation 0.70
- Small-intestinal absorptive signature · correlation 0.64
- Small-intestinal lipid metabolism · correlation 0.62
- Peptidergic neuronal-type genes · correlation 0.61
- RARRES1/PCSK5 small-bowel program · correlation 0.60
- CLU/PDZK1 I-cell program · correlation 0.54
- Goblet-like secretory progenitor · correlation 0.47
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.