Proximal regional identity
Gene co-expression module in Enteroendocrine cells
| Category | EEC development |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 14 genes have a known function matching the annotation |
Why this annotation
The hub genes ADGRG4, FAXDC2, MFSD2A, PRKG2, ADH6 and APOA1 are small-intestinal, largely proximal epithelial regional markers. They concentrate in duodenal/jejunal I, K and EC cells rather than in colonic subsets, so the module reads as a proximal small-intestine regional axis of EECs, although some enterocyte ambient signal for APOA1 cannot be excluded.
Genes
Most correlated modules
- SCN3A/HCN1 EC excitability · correlation 0.86
- Peptide tyrosine sulfation · correlation 0.85
- Villus enterocyte-like state · correlation 0.84
- RASGRP1/MME K-cell signaling · correlation 0.82
- Small-intestinal nutrient metabolism · correlation 0.81
- TAC1/RPRML small-bowel EEC · correlation 0.81
- Villus EC subpopulation · correlation 0.79
- Peptidergic neuronal-type genes · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.