LMX1B/OR51E1 EC-primed precursor
Gene co-expression module in Enteroendocrine cells
| Category | EEC development |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 14 genes have a known function matching the annotation |
Why this annotation
The core hubs LMX1B (an EC-lineage transcription factor) and OR51E1 (an EC sensory receptor) peak sharply in pre_EEC alongside MYT1 and the colonic positional gene HOXA9. This suggests an EC-primed, likely colonic, precursor state, which is set apart from PAX4/NKX2-2 specification and CDKN1C cycle-exit progenitor by its EC-lineage factors. CD96 and TSPAN18 lack a developmental role.
Genes
Most correlated modules
- RASGRP1/MME K-cell signaling · correlation 0.68
- PAX4/NKX2-2 specification · correlation 0.60
- NEUROG3+ endocrine progenitor · correlation 0.60
- Chaperonin/MYC growth genes · correlation 0.59
- CDKN1C cycle-exit progenitor · correlation 0.58
- CES1/TRPC7 EC subset · correlation 0.57
- HES6 progenitor commitment · correlation 0.57
- Progenitor hnRNP program · correlation 0.54
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.