Posterior HOX code
Gene co-expression module in Enteroendocrine cells
| Category | chromatin regulation & transcription |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 5 of 18 genes have a known function matching the annotation |
Why this annotation
Core hubs are posterior HOX genes HOXB13, HOXD10/11/13 with distal-colon-restricted PRAC1, marking regional positional identity spread modestly across colonic EEC subsets; colonocyte flags reflect the shared regional code, not contamination.
Genes
Most correlated modules
- FHL1/SCN8A EC state · correlation 0.84
- ELAVL4 post-transcriptional axis · correlation 0.80
- CADM1/ANK2 adhesion axis · correlation 0.79
- EC Calcium-Triggered Exocytosis · correlation 0.77
- Colonic L-cell identity · correlation 0.73
- SYT4+ vesicle state · correlation 0.69
- D/L-cell lineage signature · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.