SYT4+ vesicle state
Gene co-expression module in Enteroendocrine cells
| Category | Enterochromaffin program |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
Core hubs SYT4 (vesicle exocytosis), TGM6, SLC22A17 and NR0B1 are 3-8x enriched in EC cells, and the Ca2+-pump ATP2A2 supports an EC-specific secretory/vesicle state rather than contamination; it sits alongside the EC/D-shared «Neuropod Synaptic Machinery» but is defined by granule/Ca2+-handling genes rather than presynaptic scaffolds.
Genes
Most correlated modules
- ADRA1B/SYNGR4 EC subset · correlation 0.84
- NAT8L/APOD EC subset · correlation 0.83
- FHL1/SCN8A EC state · correlation 0.82
- TRPM3/KCNIP1 EC signaling · correlation 0.81
- EC accessory genes · correlation 0.80
- Neuron-like excitability · correlation 0.79
- EC Calcium-Triggered Exocytosis · correlation 0.78
- RXFP4+ EC signature · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.