ELAVL4 post-transcriptional axis
Gene co-expression module in Enteroendocrine cells
| Category | EEC development |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 3 of 12 genes have a known function matching the annotation |
Why this annotation
Hub ELAVL4 (HuD) with JAKMIP2 and AUTS2 indicates a neuron-like post-transcriptional/maturation program shared across EEC subsets; its strong correlation with «Posterior HOX code» and the neuropod modules supports a colonic neuron-like EEC axis rather than DC contamination, since no canonical DC markers are present.
Genes
Most correlated modules
- Posterior HOX code · correlation 0.80
- L-cell Ciliary Genes · correlation 0.74
- EC/D presynaptic machinery · correlation 0.72
- CADM1/ANK2 adhesion axis · correlation 0.70
- D/L-cell lineage signature · correlation 0.65
- Sensory GPCR/cadherin · correlation 0.62
- BAIAP3/CHCHD6 immature axis · correlation 0.61
- Colonic L-cell identity · correlation 0.60
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.