D/L-cell lineage signature
Gene co-expression module in Enteroendocrine cells
| Category | EEC development |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 12 genes have a known function matching the annotation |
Why this annotation
Core genes (MTURN, KIF5C, RNF2, GAB1, ITM2C) are shared at similar folds by D, L and INSL5 cells and depleted in enterochromaffin cells, marking the peptidergic branch. GALR1, PRKAA2 and SOX9 support a shared lineage program of this branch, though without hormone genes the precise biology is uncertain.
Genes
Most correlated modules
- L/D-cell excitability genes · correlation 0.85
- L-cell receptor/adhesion program · correlation 0.83
- CADM1/ANK2 adhesion axis · correlation 0.82
- L-cell Ciliary Genes · correlation 0.80
- L-cell Accessory Program · correlation 0.79
- Posterior HOX code · correlation 0.69
- ELAVL4 post-transcriptional axis · correlation 0.65
- Peptidergic branch genes · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.