Colonic L-cell identity
Gene co-expression module in Enteroendocrine cells
| Category | l cell program |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 21 genes have a known function matching the annotation |
Why this annotation
Most hubs (NEU4, CYP2W1, KCNN2, SAMD13, MPPED2) and FAM3D (5.3x) peak in L cells with a weaker INSL5 signal; colonocyte-typical genes are localized to L cells rather than spread, indicating a colon-regional L-cell state rather than contamination.
Genes
Most correlated modules
- L-cell Accessory Program · correlation 0.79
- Posterior HOX code · correlation 0.73
- L-cell VSTM2A program · correlation 0.73
- Colonic INSL5+ L-cell · correlation 0.65
- L-cell identity program · correlation 0.63
- D/L-cell lineage signature · correlation 0.61
- ELAVL4 post-transcriptional axis · correlation 0.60
- Crypt-positioned EEC state · correlation 0.58
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.