FHL1/SCN8A EC state
Gene co-expression module in Enteroendocrine cells
| Category | Enterochromaffin program |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
Every gene is enriched in EC cells and the module is core-coherent. The hubs SCN8A (Nav1.6), GRK3, ACP3 and FHL1 (12.5x) mark an excitable, GPCR-regulated EC state. It sits tightly with the CDH22/SPATA17 EC markers and EC Calcium-Triggered Exocytosis modules, which supports EC identity, but its exact functional subtype is unresolved.
Genes
Most correlated modules
- CDH22/SPATA17 EC markers · correlation 0.93
- EC Calcium-Triggered Exocytosis · correlation 0.92
- EC accessory genes · correlation 0.92
- SYT1/ATP6V1C2 vesicle genes · correlation 0.90
- Neuron-like excitability · correlation 0.87
- NAT8L/APOD EC subset · correlation 0.86
- SV2C/KCNS3 EC program · correlation 0.86
- TRPM3/KCNIP1 EC signaling · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.