EC Calcium-Triggered Exocytosis
Gene co-expression module in Enteroendocrine cells
| Category | Enterochromaffin program |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 15 genes have a known function matching the annotation |
Why this annotation
The hubs RAB3B and RAB27A (dense-core granule exocytosis), CACNA1D (Cav1.3, which drives Ca2+-triggered serotonin release), CAMK2D and ASIC2 form a stimulus–secretion coupling program with about 2x EC enrichment. Its strong correlation with the CDH22/SPATA17 EC markers and FHL1/SCN8A EC state modules supports an EC context, though a generic EEC secretory program remains possible.
Genes
Most correlated modules
- FHL1/SCN8A EC state · correlation 0.92
- CDH22/SPATA17 EC markers · correlation 0.89
- TRPM3/KCNIP1 EC signaling · correlation 0.87
- SYT1/ATP6V1C2 vesicle genes · correlation 0.85
- CADM1/ANK2 adhesion axis · correlation 0.84
- SV2C/KCNS3 EC program · correlation 0.83
- Synaptic scaffold/regulators · correlation 0.81
- EC accessory genes · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.