TCA Cycle OxPhos
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes SUCLG1 (succinyl-CoA ligase, TCA cycle) and MDH2 (malate dehydrogenase, TCA cycle) anchor this module in mitochondrial TCA cycle metabolism. SDHD (succinate dehydrogenase subunit D, Complex II) bridges TCA and ETC. ATP5F1C and ATP5PO are ATP synthase subunits (Complex V), NDUFB9 is Complex I, PHB2 is mitochondrial prohibitin (cristae organization). PEBP1 (Raf kinase inhibitor/RKIP) and ESD are peripheral. This module represents TCA cycle + OxPhos, complementing neighbor M57 (pure ETC). Both are strongly downregulated in IBD inflammation.
Genes
Most correlated modules
- Oxidative Phosphorylation · correlation 0.97
- Epithelial Lipid Homeostasis · correlation 0.96
- Mitochondrial Complex I · correlation 0.95
- ER Protein Folding · correlation 0.94
- SUMOylation & Splicing · correlation 0.94
- Translation Initiation · correlation 0.94
- Oxidative Phosphorylation · correlation 0.94
- Mitochondrial Membrane · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.