Mitochondrial Complex I
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
Three of the top hub genes are mitochondrial Complex I (NADH dehydrogenase) subunits: NDUFV2 (core subunit, NADH-binding), NDUFA8 (accessory subunit), and NDUFB8 (membrane arm subunit). DMAC1 is a Complex I assembly factor. ATP5MC1 is an ATP synthase subunit (Complex V). PARK7 (DJ-1) is a mitochondrial oxidative stress sensor and Parkinson's-associated protein. NEDD8 is the neddylation modifier that activates cullin-RING ubiquitin ligases; PSMA7 is a proteasome alpha subunit. BRK1 is part of the WAVE/SCAR complex. The dominant program is mitochondrial respiratory chain (Complex I), with NEDD8/PSMA7 as peripheral proteasome neighbors. The CD-specific downregulation with treatment recovery is consistent with mitochondrial dysfunction in IBD. Neighbor context: adjacent to M51 (proteasome/ER) explaining the NEDD8/PSMA7 co-expression.
Genes
Most correlated modules
- ER Protein Processing · correlation 0.95
- SUMOylation & Splicing · correlation 0.95
- Mitochondrial Membrane · correlation 0.95
- TCA Cycle OxPhos · correlation 0.95
- Metabolic Housekeeping · correlation 0.94
- snRNP Splicing Complex · correlation 0.94
- snRNP RNA Processing · correlation 0.94
- Oxidative Phosphorylation · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.