Mitochondrial Membrane
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes DBI (diazepam binding inhibitor/acyl-CoA binding protein, mitochondrial lipid transport), ATP5MC3 (ATP synthase subunit c, Complex V), COX8A (cytochrome c oxidase subunit 8A, Complex IV), PRELID1 (mitochondrial lipid transfer, cardiolipin biosynthesis), TSPO (translocator protein, outer mitochondrial membrane), CHCHD2 (mitochondrial intermembrane space, Complex IV assembly). MGST1 is microsomal glutathione transferase. PFN1 (profilin, actin) is a peripheral member. This module is centered on mitochondrial inner membrane and lipid homeostasis supporting OxPhos. Neighbor to M57 and M79, forming a coherent mitochondrial neighborhood. Downregulated in both UC and CD inflammation.
Genes
Most correlated modules
- Oxidative Phosphorylation · correlation 0.96
- Metabolic Housekeeping · correlation 0.96
- Mitochondrial Sulfur Detox · correlation 0.95
- Oxidative Phosphorylation · correlation 0.95
- Mitochondrial Complex I · correlation 0.95
- TCA Cycle OxPhos · correlation 0.94
- ER Protein Trafficking · correlation 0.94
- ER Protein Processing · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.