Metabolic Housekeeping
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 13 genes have a known function matching the annotation |
Why this annotation
This module has weak-to-moderate membership for most hub genes (GAPDH weak, ARPC5 weak, CFL1 weak, RALA weak), indicating a mixed/poorly defined program. GAPDH (glycolysis), ECHS1 (mitochondrial fatty acid beta-oxidation), TUFM (mitochondrial translation elongation factor), PRDX2 (cytoplasmic peroxiredoxin), GSTP1 (glutathione S-transferase) suggest general metabolic housekeeping. PPIA (cyclophilin A), SSR4 (translocon), AGR2 (ER protein disulfide isomerase) add ER/protein folding components. CFL1, ARPC5, RHOA are cytoskeletal. The module appears to be a mixed housekeeping module combining glycolysis, redox, and cytoskeletal elements. Moderate downregulation in CD inflammation only.
Genes
Most correlated modules
- ER Protein Trafficking · correlation 0.97
- Mitochondrial Membrane · correlation 0.96
- Oxidative Phosphorylation · correlation 0.95
- ER Protein Folding · correlation 0.95
- Mitochondrial Complex I · correlation 0.94
- snRNP RNA Processing · correlation 0.94
- Metabolic Housekeeping · correlation 0.94
- TCA Cycle OxPhos · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.