ER Protein Folding
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 14 genes have a known function matching the annotation |
Why this annotation
Top hub PDIA6 is an ER protein disulfide isomerase; TMED2 is a COPI vesicle cargo receptor in the early secretory pathway; PPIB (cyclophilin B) is an ER luminal peptidyl-prolyl isomerase; SPCS2 is a signal peptidase complex subunit; MYDGF is an ER-derived secreted growth factor. GDI2 regulates Rab GTPase recycling in vesicular transport. VDAC1 and ARPC2 are peripheral members. The module is dominated by ER protein folding and early secretory pathway components. Neighbor to M5 (ER trafficking) and M57 (OxPhos), consistent with a housekeeping secretory program.
Genes
Most correlated modules
- ER Protein Trafficking · correlation 0.96
- Metabolic Housekeeping · correlation 0.95
- TCA Cycle OxPhos · correlation 0.94
- ER Protein Processing · correlation 0.94
- Oxidative Phosphorylation · correlation 0.94
- SUMOylation & Splicing · correlation 0.94
- Mitochondrial Complex I · correlation 0.94
- snRNP RNA Processing · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.