ER Protein Trafficking
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes include KDELR2 (KDEL receptor for ER retrieval), RER1 (ER retention of membrane proteins), BCAP31 (ER membrane protein), ERP29 (ER luminal protein processing), PRDX4 (ER-localized peroxiredoxin/oxidoreductase), and AP1M2 (epithelial-specific clathrin adaptor involved in basolateral sorting). ARPC1A and CAPZB are actin regulators, TALDO1 is pentose phosphate pathway. The ER trafficking/retention genes dominate the top PageRank positions. Downregulated in CD inflammation, restored by CD treatment, consistent with a housekeeping ER function suppressed during active disease.
Genes
Most correlated modules
- Metabolic Housekeeping · correlation 0.97
- Oxidative Phosphorylation · correlation 0.96
- ER Protein Folding · correlation 0.96
- snRNP RNA Processing · correlation 0.94
- Mitochondrial Membrane · correlation 0.94
- Metabolic Housekeeping · correlation 0.94
- Mitochondrial Complex I · correlation 0.93
- TCA Cycle OxPhos · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.