ER Targeting & Trafficking
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 16 genes have a known function matching the annotation |
Why this annotation
CSDE1 (CSD-containing RNA-binding protein, regulates mRNA stability/translation), SRP72 (signal recognition particle, ER targeting), RCN2 (ER calcium-binding protein), ARL6IP5 (ER/Golgi membrane protein), ATP6AP2 (V-ATPase accessory/renin receptor, ER/endosome), RAB14 (endosomal trafficking), ACSL5 (long-chain fatty acyl-CoA synthetase, ER-associated), METTL9 (methyltransferase), ST13 (Hsc70 co-chaperone), CPNE3 (calcium-dependent membrane binding), CD47 (anti-phagocytic signal), CCNI (cyclin I, non-mitotic), MTPN (myotrophin, actin capping), NSA2 (ribosome biogenesis), CMPK1 (nucleotide metabolism), TMEM123. The module combines ER targeting/processing, vesicular trafficking, and general cellular maintenance. SRP72, RCN2, ARL6IP5, ATP6AP2 link it to the ER/trafficking neighborhood of M87 and M24. Strong membership across most genes supports a coherent program.
Genes
Most correlated modules
- ER Protein Folding · correlation 0.93
- Housekeeping Transcription · correlation 0.93
- RNA Processing Translation · correlation 0.92
- TRiC Chaperonin Complex · correlation 0.92
- SUMOylation & Splicing · correlation 0.92
- Epithelial Lipid Homeostasis · correlation 0.91
- Translation Initiation · correlation 0.91
- ER Membrane Organization · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.