Mitochondrial Cristae Organization
Gene co-expression module in Lymphatic endothelial
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 15 genes have a known function matching the annotation |
Why this annotation
MICOS10 and MICOS13 are core subunits of the mitochondrial contact site and cristae organizing system (MICOS complex), which maintains inner mitochondrial membrane architecture. NDUFA13 is a Complex I subunit, ATP5MJ is an ATP synthase subunit, and ATP6V0C is a V-ATPase subunit. Together these genes define mitochondrial inner membrane organization and oxidative phosphorylation. Additional genes EEF1G, EIF4A1 (translation), SNRPN (splicing), and MIF (cytokine/housekeeping) are peripheral. Uniform expression and moderate pct positive (46.1%) are consistent with constitutive mitochondrial maintenance. Neighbor modules M72 and M62 also represent housekeeping programs, confirming this batch reflects general metabolic/housekeeping co-expression.
Genes
ATP5MJ, ATP6V0C, BEX4, EEF1G, EIF4A1, KRTCAP2, MICOS10, MICOS13, MIF, NDUFA13, NME2, RNASEK, SNRPN, TMEM35B, TRAPPC5
Most correlated modules
- Oxidative Phosphorylation · correlation 0.74
- Protein Quality Control · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.