Protein Quality Control
Gene co-expression module in Lymphatic endothelial
| Category | Protein processing & ER |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
SKP1 is a core component of the SCF ubiquitin E3 ligase complex involved in protein ubiquitination and degradation. PFDN5 is a prefoldin subunit involved in chaperone-mediated protein folding. BCAP29 is an ER membrane protein involved in protein processing. CDC42 is a Rho GTPase involved in cytoskeletal and vesicle regulation. NDUFV2 and SLC25A6 contribute mitochondrial/metabolic components. The module reflects a general protein quality control and processing program. Uniform expression and moderate pct positive (59.8%) are consistent with housekeeping activity. Neighbors M72 and M53 reinforce a housekeeping cluster interpretation.
Genes
BCAP29, CD99, CDC42, DYNLRB1, GNG5, NDUFV2, PDCD6, PFDN5, SKP1, SLC25A6
Most correlated modules
- Actomyosin Cytoskeleton · correlation 0.82
- 20S Proteasome Core · correlation 0.76
- MHC-I Antigen Presentation · correlation 0.75
- Mitochondrial OxPhos Complex · correlation 0.75
- mRNA Translation Regulation · correlation 0.73
- Translation Elongation · correlation 0.72
- Proteasome Assembly · correlation 0.70
- Mitochondrial Cristae Organization · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.