MICOS13 — Mitochondrial contact site and cristae organizing system subunit 13
MICOS13 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MICOS13's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Mitochondrial Dynamics Mitochondrial & OxPhos | ATP5MC1, ECHS1, EDF1, FIS1, FRA10AC1, HIGD2A, IFNAR2, MRI1 +2 more | |
| Innate lymphoid cells | Mitochondrial Organization Mitochondrial & OxPhos | ARL5A, ATP5MJ, ATP5MK, BBLN, C18orf32, CIAO2B, CYRIB, EEF1G +21 more | View in SCUBA |
| Lymphatic endothelial | Mitochondrial Cristae Organization Mitochondrial & OxPhos | ATP5MJ, ATP6V0C, BEX4, EEF1G, EIF4A1, KRTCAP2, MICOS10, MIF +6 more | View in SCUBA |
| Macrophages | Oxidative Phosphorylation Mitochondrial & OxPhos | ATP5F1C, ATP5MC3, ATP5PD, ATP5PO, COX5B, COX6C, LAMTOR2, MICOS10 +7 more | View in SCUBA |
| Mucosal-associated invariant T cell | Leukocyte Housekeeping Housekeeping | AP2S1, APRT, ATP5MC2, CCDC85B, EIF3G, ERP29, GABARAPL2, GMFG +5 more |
About the gene
| Synonyms | C19orf70, MIC12, MIC13, P117, QIL1 |
|---|---|
| Chromosome | 19: 5678421-5680516 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
Function
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Constituent of mature MICOS complex, it is required for the formation of cristae junction (CJ) and maintenance of cristae morphology. Required for the incorporation of MICOS10/MIC10 into the MICOS complex.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.