BEX4 — Brain expressed X-linked 4
BEX4 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BEX4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Redox Stress Response Stress | BEX2, CITED4, EEF1A1, FMNL3, FTL, GRINA, LTBP3, MICAL1 +5 more | |
| Glial cells | Lysosomal Sphingolipid Metabolism Housekeeping | ASAH1, CLIC4, EID1, LAMP1, PSAP, SERPINB6, SGCE, SSPN | View in SCUBA |
| Lymphatic endothelial | Mitochondrial Cristae Organization Mitochondrial & OxPhos | ATP5MJ, ATP6V0C, EEF1G, EIF4A1, KRTCAP2, MICOS10, MICOS13, MIF +6 more | View in SCUBA |
| Natural Killer cells | Glucocorticoid Response Immune regulation | AREG, ARF6, BCLAF1, BEX2, ELF1, ELL2, EPC1, GABARAPL1 +11 more | View in SCUBA |
About the gene
| Synonyms | BEXL1, FLJ10097 |
|---|---|
| Chromosome | X: 103215108-103217246 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
May play a role in microtubule deacetylation by negatively regulating the SIRT2 deacetylase activity toward alpha-tubulin and thereby participate in the control of cell cycle progression and genomic stability. In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.