Oxidative Phosphorylation
Gene co-expression module in Lymphatic endothelial
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 12 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
Module contains a second set of ATP synthase subunits (ATP5MG, ATP5MC2, ATP5F1E, ATP5F1D, ATP5ME) complementing those in neighbor M51, plus COX7C (Complex IV), UQCRB (Complex III), and TOMM7 (mitochondrial outer membrane translocase for protein import). Together with M51, this module represents a split of the core oxidative phosphorylation gene network. Peripheral genes COMMD6, MZT2B, EIF3K, and PPDPF are weakly associated co-travelers. Uniform expression and high detection rate are consistent with housekeeping mitochondrial metabolism.
Genes
ATP5F1D, ATP5F1E, ATP5MC2, ATP5ME, ATP5MG, COMMD6, COX7C, EIF3K, MZT2B, PPDPF, TOMM7, UQCRB
Most correlated modules
- Mitochondrial OxPhos Complex · correlation 0.92
- Housekeeping Mixed · correlation 0.90
- Oxidative Phosphorylation · correlation 0.89
- Mitochondrial OxPhos Complex · correlation 0.84
- Actomyosin Cytoskeleton · correlation 0.83
- Fatty Acid Oxidation · correlation 0.82
- Caveolae Cytoskeletal · correlation 0.81
- Mitochondrial OxPhos Complex · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.