KRTCAP2 — Keratinocyte associated protein 2
KRTCAP2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KRTCAP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | AKT survival signaling TCR/AP1/NFKb pathway | ABHD2, AKT1, ARL14EP, ATF7, ATP6AP1, CHD8, GNGT2, IP6K2 +10 more | View in SCUBA |
| Gamma-delta T cells | NKG2D Cytotoxic Activation cytotoxicity | CCND3, GABARAP, HCST, HDAC10, IER3IP1, IL2RG, KLRK1, LAMTOR4 +11 more | |
| Innate lymphoid cells | NK Activating Receptors Cytotoxicity | CAT, CRACDL, ELAPOR1, FLT3LG, KLRK1, LTA4H, MFSD10, MLLT3 +7 more | View in SCUBA |
| Lymphatic endothelial | Mitochondrial Cristae Organization Mitochondrial & OxPhos | ATP5MJ, ATP6V0C, BEX4, EEF1G, EIF4A1, MICOS10, MICOS13, MIF +6 more | View in SCUBA |
| Mucosal-associated invariant T cell | ER Glycosylation & Ubiquitin Protein processing & ER | AIP, ALDOA, ATP5MG, COX6A1, COX6B1, ELOB, FIS1, GAPDH +9 more | |
| Smooth muscle cells | Proliferative Biosynthesis Housekeeping | ARF5, BUB3, CBX5, DCTN3, DUT, HMGN2, IDH2, MIF +7 more | View in SCUBA |
About the gene
| Synonyms | KCP2 |
|---|---|
| Chromosome | 1: 155169408-155173475 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
Function
Subunit of STT3A-containing oligosaccharyl transferase (OST- A) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N- glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). Within the OST-A complex, acts as an adapter that anchors the OST-A complex to the Sec61 complex. May be involved in N-glycosylation of APP (amyloid- beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.