Interferon Antigen Processing
Gene co-expression module in Microfold-like cells
| Category | Antigen handling |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes include HLA-DMA (MHC class II antigen processing chaperone), PSMB9 (immunoproteasome subunit β1i, interferon-γ induced), IFITM3 (interferon-induced transmembrane protein 3), PCNA (proliferating cell nuclear antigen, DNA replication/repair), CKS2 (cell cycle kinase regulatory subunit), SMC4 (structural maintenance of chromosomes, mitosis), DEK (chromatin remodeling oncogene), TDP2 (tyrosyl-DNA phosphodiesterase 2, DNA repair), TAGLN2 (actin binding), SULT1B1 (colonocyte sulfotransferase), SDHA (succinate dehydrogenase). The antigen processing/interferon genes (HLA-DMA, PSMB9, IFITM3) co-occur with cell cycle genes (PCNA, CKS2, SMC4), suggesting a mixed module of interferon-stimulated antigen processing and proliferative activity, possibly in inflammatory M_like cells responding to IFN-γ. Increased with CD treatment.
Genes
Most correlated modules
- Inflammatory Activation Stress · correlation 0.98
- Colonocyte Proliferative Recovery · correlation 0.97
- Antigen Presentation Housekeeping · correlation 0.97
- Mitochondrial Assembly · correlation 0.96
- Absorptive Colonocyte Identity · correlation 0.96
- Mucosal Restitution Secretory · correlation 0.95
- Colonocyte Metabolic Homeostasis · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.