Phagocytic Lipid Catabolism
Gene co-expression module in Microfold-like cells
| Category | Antigen handling |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
SYK is the central kinase downstream of Fc receptors and pattern recognition receptors driving phagocytosis; GM2A is a lysosomal lipid transfer protein required for ganglioside degradation; NCEH1 (neutral cholesterol ester hydrolase) hydrolyzes cholesterol esters in lysosomes; SERPINA1 (alpha-1-antitrypsin) is a serine protease inhibitor secreted by macrophages; PIK3AP1 is a PI3K adaptor involved in B-cell/macrophage receptor signaling; HS3ST1 modifies heparan sulfate. The SYK-PIK3AP1-GM2A-NCEH1 axis strongly points to phagocytic receptor signaling coupled to lysosomal lipid catabolism, a hallmark of macrophage phagocytosis.
Genes
Most correlated modules
- Lipid Mediator Signaling · correlation 0.99
- IL1B Inflammatory Macrophage · correlation 0.98
- Sphingolipid Membrane Organization · correlation 0.98
- Vesicle Membrane Trafficking · correlation 0.98
- Interferon Chemokine Response · correlation 0.97
- WNT-BMP Morphogenic · correlation 0.97
- Non-canonical NF-κB · correlation 0.97
- Absorptive Enterocyte · correlation 0.97
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.