Sphingolipid Membrane Organization
Gene co-expression module in Microfold-like cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
CAV1 (caveolin-1) is the structural protein of caveolae and a master regulator of lipid raft-mediated cholesterol trafficking; UGCG (UDP-glucose ceramide glucosyltransferase) is the rate-limiting enzyme in glucosylceramide/sphingolipid synthesis; HSD17B2 (17β-hydroxysteroid dehydrogenase 2) metabolizes steroids; CYB5R4 is a cytochrome b5 reductase involved in lipid desaturation; SORD (sorbitol dehydrogenase) participates in the polyol pathway; MCUR1 regulates mitochondrial calcium uptake. The module is anchored by CAV1 and UGCG, pointing to sphingolipid/cholesterol membrane organization. Neighbors M99 and M23 also involve lipid metabolism, confirming a lipid-centric neighborhood.
Genes
Most correlated modules
- WNT-BMP Morphogenic · correlation 0.99
- Absorptive Enterocyte · correlation 0.98
- Phagocytic Lipid Catabolism · correlation 0.98
- Lysosomal Lipid Catabolism · correlation 0.98
- Non-canonical NF-κB · correlation 0.96
- IL1B Inflammatory Macrophage · correlation 0.95
- Vesicle Membrane Trafficking · correlation 0.95
- Tissue-protective Macrophage · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.