Vesicle Membrane Trafficking
Gene co-expression module in Microfold-like cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes include GNAI2 (Gi-coupled receptor signaling), INSR (insulin receptor/metabolic signaling), JAK2 (cytokine receptor-associated kinase), SNAP23 (SNARE protein for vesicle fusion/exocytosis), ATP8A1 (phospholipid flippase maintaining membrane asymmetry), ALDH18A1 (proline biosynthesis/metabolic), and SYNPO2 (actin dynamics). This module reflects intracellular vesicle trafficking, membrane phospholipid homeostasis, and cytokine/metabolic receptor signaling in macrophages.
Genes
Most correlated modules
- Non-canonical NF-κB · correlation 0.99
- Interferon Chemokine Response · correlation 0.99
- Signaling Suppression · correlation 0.98
- Phagocytic Lipid Catabolism · correlation 0.98
- Lipid Mediator Signaling · correlation 0.97
- WNT-BMP Morphogenic · correlation 0.97
- Stress Survival Response · correlation 0.96
- Absorptive Enterocyte · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.