Tissue-protective Macrophage
Gene co-expression module in Microfold-like cells
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 12 genes have a known function matching the annotation |
Why this annotation
Module contains AIF1 (Iba1, canonical macrophage marker), SOD3 (extracellular antioxidant), SELENOM (selenoprotein antioxidant), SERPINF2 (protease inhibitor/anti-fibrinolytic), SPINK5 and CSTA (serine/cysteine protease inhibitors), LYPD8 (mucosal epithelial defense), CCL23 (macrophage-derived chemokine), and CMTM7 (immune modulator). The combination of antioxidant and protease inhibitor genes in AIF1+ macrophages, with positive remission_UC association, suggests a tissue-protective, anti-inflammatory macrophage state. MIA and MSLN are less canonical but expressed in tissue-resident contexts.
Genes
Most correlated modules
- Lipid Mediator Signaling · correlation 0.97
- WNT-BMP Morphogenic · correlation 0.97
- Phagocytic Lipid Catabolism · correlation 0.96
- Interferon Chemokine Response · correlation 0.96
- Non-canonical NF-κB · correlation 0.96
- IL1B Inflammatory Macrophage · correlation 0.95
- Vesicle Membrane Trafficking · correlation 0.95
- Sphingolipid Membrane Organization · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.