Oxidative Stress Response
Gene co-expression module in Microfold-like cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
NFE2L2 (NRF2, master oxidative stress TF), PRDX3 (mitochondrial peroxiredoxin), HERPUD1 (ER stress/UPR component), G3BP1 (stress granule nucleator), RAD23A (DNA damage/proteasome shuttle), and TPR (nuclear pore, stress-responsive) collectively define an oxidative and proteotoxic stress response program. NFE2L2 is the canonical driver of antioxidant gene expression. PRDX3 detoxifies mitochondrial ROS. HERPUD1 is induced by ER stress. G3BP1 nucleates stress granules under cellular stress. The module is significantly decreased in CD inflammation and restored by CD treatment, consistent with a homeostatic stress-defense program suppressed during active disease.
Genes
Most correlated modules
- ER Protein Homeostasis · correlation 0.99
- Antigen Presentation Housekeeping · correlation 0.99
- Heat Shock Response · correlation 0.99
- ER Protein Folding · correlation 0.99
- Chaperone Proteostasis · correlation 0.99
- Apoptosis Regulation · correlation 0.98
- Protein Homeostasis · correlation 0.98
- Protein Processing ER · correlation 0.98
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.