Apoptosis Regulation
Gene co-expression module in Microfold-like cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes include CASP6 (caspase-6, apoptosis executioner), BCLAF1 (BCL2-associated transcription factor, apoptosis regulator), ROCK2 (Rho kinase, apoptosis/cytoskeletal signaling), PTP4A2 (phosphatase modulating survival signaling), and RNA-binding proteins PTBP3, FAM120A, SYNCRIP that regulate apoptotic mRNA processing. The module combines apoptosis execution and its RNA-level regulation. Significant response to CD treatment supports a regulated cell death program in M-like cells.
Genes
Most correlated modules
- Protein Homeostasis · correlation 0.99
- Membrane Trafficking · correlation 0.99
- Intracellular Cargo Transport · correlation 0.99
- ER Protein Folding · correlation 0.99
- DNA Damage Response · correlation 0.99
- Macrophage Homeostasis · correlation 0.99
- Membrane Remodeling mTOR · correlation 0.98
- Metabolic Housekeeping · correlation 0.98
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.