ER Protein Folding
Gene co-expression module in Microfold-like cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 15 genes have a known function matching the annotation |
Why this annotation
HSP90B1 (GRP94, major ER chaperone), SELENOF (ER-resident selenoprotein involved in oxidative protein folding), KTN1 (kinectin, ER membrane protein), CCT3 (chaperonin TRiC/CCT subunit), PSMD7 (proteasome 19S regulatory subunit), YWHAE (14-3-3 epsilon, protein interaction scaffold), RHOA (Rho GTPase), CALM1 (calmodulin), and ANXA2 collectively define an ER protein folding and proteasomal degradation program. HSP90B1 and SELENOF are canonical ER quality control components. CCT3 folds newly synthesized proteins. PSMD7 mediates ERAD. This module is the most ER-centric in the batch, complementing the cytosolic chaperone focus of M38 and the oxidative stress focus of M27.
Genes
Most correlated modules
- Macrophage Homeostasis · correlation 0.99
- Epithelial Metabolic Housekeeping · correlation 0.99
- Apoptosis Regulation · correlation 0.99
- Oxidative Stress Response · correlation 0.99
- Metabolic Detoxification · correlation 0.98
- ER Protein Homeostasis · correlation 0.98
- Chaperone Proteostasis · correlation 0.98
- Colonocyte Differentiation · correlation 0.98
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.