Chaperone Proteostasis
Gene co-expression module in Microfold-like cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
YBX1 (multifunctional RNA-binding protein and stress response factor), HSP90AB1 (cytosolic Hsp90 chaperone), ST13 (Hsp70 co-chaperone/CHIP), HNRNPA0 and PCBP2 (RNA-binding proteins), TOMM20 (mitochondrial outer membrane import receptor), HMGN1 (chromatin), and TRIM2 (ubiquitin E3 ligase) together reflect a chaperone-mediated protein quality control and RNA-binding stress program. YBX1 and HSP90AB1 are central to proteostasis under stress. ST13 facilitates Hsp70-mediated protein folding. CCND2 adds a cell cycle component. Neighbor to M27 (oxidative stress) and M2 (ER protein processing), supporting a broader proteostasis neighborhood. Significantly decreased in inflammation and restored by CD treatment.
Genes
Most correlated modules
- Housekeeping Mixed · correlation 0.99
- ER Protein Homeostasis · correlation 0.99
- Oxidative Stress Response · correlation 0.99
- OxPhos & Mitochondrial · correlation 0.98
- ER Protein Folding · correlation 0.98
- Colonocyte Differentiation · correlation 0.98
- Oxidative Phosphorylation · correlation 0.98
- OxPhos & Mitochondrial · correlation 0.98
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.