Macrophage Homeostasis
Gene co-expression module in Microfold-like cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes KLF5 (macrophage/epithelial homeostasis TF), EZR (ezrin, membrane-cytoskeletal linker), RAB10 (vesicle trafficking), SERPINB1 (protease inhibitor), DDX18 (RNA helicase), CCNI (cyclin I), and SUB1 collectively reflect a macrophage homeostatic identity program. KLF5 is a master regulator of macrophage and intestinal cell homeostasis. EZR and RAB10 support membrane organization and vesicle trafficking. SERPINB1 protects against protease-mediated damage. The uniform expression and significant CD treatment response suggest restoration of homeostatic macrophage identity upon treatment.
Genes
Most correlated modules
- Growth Arrest Stress · correlation 0.99
- ER Protein Folding · correlation 0.99
- Endosomal Vesicle Trafficking · correlation 0.99
- Apoptosis Regulation · correlation 0.99
- Intracellular Cargo Transport · correlation 0.99
- Epithelial Identity · correlation 0.99
- Colonocyte Differentiation · correlation 0.98
- Metabolic Detoxification · correlation 0.98
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.