Cholinergic secretory signaling
Gene co-expression module in Paneth cells
| Category | Secretion |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 3 of 10 genes have a known function matching the annotation |
Why this annotation
CHRM3 (M3 muscarinic receptor) and PLCB4 (Gq-coupled phospholipase C) together form the cholinergic signaling axis that triggers Paneth cell degranulation. PTPRN2 (phogrin) is a dense-core secretory granule membrane protein. The remaining genes (LARP1B, FNDC3A/B, SORBS1, ANKH, SLC12A8, BCAS1) are long genes with less specific links. The cholinergic hubs pair with M20 exocytosis machinery, suggesting stimulus–secretion coupling. The partial long-gene/nuclear artifact character tempers confidence.
Genes
Most correlated modules
- Regulated granule exocytosis · correlation 0.85
- Transcription factor program · correlation 0.63
- Long-gene nuclear transcripts · correlation 0.62
- Vesicle trafficking · correlation 0.30
- Rho GTPase regulation · correlation 0.28
- hnRNP mRNA processing · correlation 0.22
- Chromatin remodeling · correlation 0.21
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.