hnRNP mRNA processing
Gene co-expression module in Paneth cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
The hubs are hnRNP family RNA-binding proteins (HNRNPA3, HNRNPU, HNRNPA2B1), together with the chromatin histone variant MACROH2A1 and the transcription factor GTF2I. The remaining genes (PGAP1, LIMA1, ADD3) are long transcripts. This set is typical of a nuclear-retained, long-transcript and RNA-binding protein signature, reflecting pre-mRNA processing and nuclear RNA content. A partial technical (nuclear fraction) component is possible. Expression is uniform and the module is core-coherent. It is distinct from the secretory and stress neighbors.
Genes
Most correlated modules
- Mitochondrial biogenesis · correlation 0.76
- Progenitor-like differentiation · correlation 0.61
- Transcription factor program · correlation 0.56
- Chaperone proteostasis stress · correlation 0.55
- Translation machinery · correlation 0.53
- Electron transport chain · correlation 0.47
- Translation elongation · correlation 0.45
- Chromatin remodeling · correlation 0.43
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.