Chromatin remodeling
Gene co-expression module in Paneth cells
| Category | chromatin regulation & transcription |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 7 genes have a known function matching the annotation |
Why this annotation
Core members are chromatin modifiers and remodelers. These are KANSL1 (NSL/MOF H4K16 acetyltransferase complex), ARID1B (SWI/SNF BAF subunit), ANKRD11 (HDAC-associated chromatin regulator), MLLT3 (super elongation complex/DOT1L partner) and PAWR (transcriptional corepressor). Coherence is tight and expression uniform. The pattern indicates a chromatin remodeling program, likely capturing nuclear long-gene transcripts, and it neighbors M16 (TF program).
Genes
Most correlated modules
- Granule transport · correlation 0.52
- Chromatin remodeling regulators · correlation 0.52
- Long-gene nuclear transcripts · correlation 0.48
- Regulated granule exocytosis · correlation 0.47
- hnRNP mRNA processing · correlation 0.43
- Rho GTPase regulation · correlation 0.36
- Long-gene nuclear transcripts · correlation 0.26
- Transcription factor program · correlation 0.23
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.