Transcription factor program
Gene co-expression module in Paneth cells
| Category | chromatin regulation & transcription |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
The module is dominated by transcription factors and zinc-finger nuclear regulators. These include PBX1 (TALE homeodomain TF), PHF14 (PHD finger chromatin reader), ZKSCAN1, ZNF292 and ZSWIM6. PTBP2 and ZFAND6 are peripheral. Expression is uniform and the genes are long, consistent with a low-level nuclear transcriptional regulatory program, possibly enriched by intronic/nuclear reads. The module clusters with M44, another chromatin regulator module.
Genes
Most correlated modules
- Long-gene nuclear transcripts · correlation 0.75
- Regulated granule exocytosis · correlation 0.72
- Cholinergic secretory signaling · correlation 0.63
- hnRNP mRNA processing · correlation 0.56
- LGR5+ crypt stemness · correlation 0.43
- Chaperone proteostasis stress · correlation 0.39
- Abundant housekeeping transcripts · correlation 0.23
- Chromatin remodeling · correlation 0.23
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.