Vesicle trafficking
Gene co-expression module in Paneth cells
| Category | Secretion |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 7 genes have a known function matching the annotation |
Why this annotation
Members point to membrane trafficking. GBF1 is an Arf GEF acting at the ER–Golgi interface, and DENND4A is a Rab10 GEF. KIF16B is a motor for early endosome transport, and SH3GL2 (endophilin A1) drives endocytic membrane curvature. TIAM2 and FGD4 are Rho/Cdc42 GEFs linked to vesicle and actin dynamics. Altogether this suggests a vesicle trafficking program relevant to Paneth granule secretion and recycling.
Genes
Most correlated modules
- Long-gene nuclear transcripts · correlation 0.87
- Rho GTPase regulation · correlation 0.64
- Long-gene nuclear transcripts · correlation 0.63
- Crypt progenitor program · correlation 0.58
- Granule transport · correlation 0.58
- Regulated granule exocytosis · correlation 0.48
- Chromatin remodeling regulators · correlation 0.42
- Cholinergic secretory signaling · correlation 0.30
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.