Long-gene nuclear transcripts
Gene co-expression module in Paneth cells
| Category | Technical artifact |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 9 genes have a known function matching the annotation |
Why this annotation
Members are very long, intron-rich genes expressed uniformly (PTK2, FOXP1, MAML3, NR6A1, RERE, ARHGAP32, ANKRD17, RBM6, TOX). They are mostly broadly acting transcriptional regulators with no coherent Paneth-specific function. This pattern typically reflects unspliced nuclear or intronic read capture, i.e. long-gene technical covariation.
Genes
Most correlated modules
- Regulated granule exocytosis · correlation 0.87
- Transcription factor program · correlation 0.75
- Vesicle trafficking · correlation 0.63
- Cholinergic secretory signaling · correlation 0.62
- Long-gene nuclear transcripts · correlation 0.57
- Chromatin remodeling · correlation 0.48
- Crypt progenitor program · correlation 0.41
- Granule transport · correlation 0.35
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.