Regulated granule exocytosis
Gene co-expression module in Paneth cells
| Category | Secretion |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 7 genes have a known function matching the annotation |
Why this annotation
The hub genes form a vesicle trafficking and regulated exocytosis machinery. EXOC4 is an exocyst component. PLD1 and PRKCA together drive phosphatidic acid and PKC-dependent granule exocytosis. RABGAP1L is a Rab GTPase regulator. AKAP9 is a Golgi/centrosome PKA scaffold. In Paneth cells this fits secretory granule release downstream of cholinergic and PKC signaling. Expression is uniform and the genes are long, so a nuclear-transcript contribution is possible. However, the functional coherence around exocytosis is notable. The module neighbors M24, which contains CHRM3 and PLCB4 (cholinergic Gq signaling), supporting a stimulus–secretion coupling axis.
Genes
Most correlated modules
- Long-gene nuclear transcripts · correlation 0.87
- Cholinergic secretory signaling · correlation 0.85
- Transcription factor program · correlation 0.72
- Vesicle trafficking · correlation 0.48
- Chromatin remodeling · correlation 0.47
- Long-gene nuclear transcripts · correlation 0.28
- Rho GTPase regulation · correlation 0.28
- hnRNP mRNA processing · correlation 0.25
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.