Baseline Maintenance Transcripts
Gene co-expression module in Smooth muscle cells
| Category | Housekeeping |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 14 genes have a known function matching the annotation |
Why this annotation
A broadly detected mixture of constitutively expressed maintenance genes: small uncharacterized ORFs (C9orf16, C8orf59), the abundant housekeeping lncRNAs NORAD and SNHG9, cytoskeletal septin SEPT2, aminoacyl-tRNA synthetase NARS, mitochondrial MICOS subunit MINOS1, histone variant H2AFY and large scaffolding genes (TTC37, KIAA1109, C9orf3). Two SMC-relevant genes (MRVI1/IRAG, CAVIN3) hint at a caveolar/cGMP flavour shared with neighbor M6, but the module as a whole reflects baseline transcriptional output rather than a discrete program.
Genes
C8orf59, C9orf16, C9orf3, CAVIN3, FAM129A, H2AFY, KIAA1109, MINOS1, MRVI1, NARS, NORAD, SEPT2, SNHG9, TTC37
Most correlated modules
- Ambient High-Expressors · correlation 0.98
- NO-cGMP Signaling · correlation 0.91
- HOX Positional Identity · correlation 0.89
- ATP Synthase Complex · correlation 0.88
- Mechanostress Early Response · correlation 0.85
- Mesenchymal lncRNA Activation · correlation 0.75
- Heat Shock Response · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.