Ambient High-Expressors
Gene co-expression module in Smooth muscle cells
| Category | Technical artifact |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 11 genes have a known function matching the annotation |
Why this annotation
Highest-expressed, most broadly detected module in the batch, composed exclusively of ubiquitous high-abundance transcripts: MALAT1, replication-independent histones H3F3A/H3F3B/H2AFZ, humanin-like mitochondrial pseudogenes MTRNR2L8/MTRNR2L12, and tiny mito/ATP synthase subunits (ATP5MD, ATP5MPL, C19orf70). This combination with uniform expression and no subset specificity is the signature of ambient RNA/library-size driven co-expression rather than a coordinated biological program; it neighbors the genuine OxPhos module M81 through shared small ATP5 transcripts.
Genes
ATP5MD, ATP5MPL, C19orf70, H2AFZ, H3F3A, H3F3B, MALAT1, MTRNR2L12, MTRNR2L8, SELENOM, SEPT7
Most correlated modules
- Baseline Maintenance Transcripts · correlation 0.98
- NO-cGMP Signaling · correlation 0.90
- Mechanostress Early Response · correlation 0.89
- HOX Positional Identity · correlation 0.89
- ATP Synthase Complex · correlation 0.88
- Mesenchymal lncRNA Activation · correlation 0.78
- Heat Shock Response · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.