CAVIN3 — Caveolae associated protein 3
CAVIN3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CAVIN3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Vascular Tone Regulation Endothelial cell development | ADAMTS6, ATP1A1, ATP1B3, ATP5PF, CALD1, CCDC3, CD81, HMOX2 +13 more | View in SCUBA |
| Fibroblasts | ECM Homeostasis ECM remodeling | CAST, FAM114A1, HCFC1R1, MXRA7, PPIC, SELENOW, TIMP2, TUBB | View in SCUBA |
| Pericytes | Focal Adhesion Cytoskeleton Cytoskeletal | ARPC5, CNN3, MAP1B, MYL6, PDLIM2, TGFB1I1, TLN1, TPM4 | View in SCUBA |
| Smooth muscle cells | Baseline Maintenance Transcripts Housekeeping | C8orf59, C9orf16, C9orf3, FAM129A, H2AFY, KIAA1109, MINOS1, MRVI1 +5 more | View in SCUBA |
About the gene
| Synonyms | cavin-3, HSRBC, MGC20400, PRKCDBP, SRBC |
|---|---|
| Chromosome | 11: 6318946-6320532 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Biological rhythms |
Function
Regulates the traffic and/or budding of caveolae. Plays a role in caveola formation in a tissue- specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface- dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.