ATP Synthase Complex
Gene co-expression module in Smooth muscle cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 17 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 17 genes have a known function matching the annotation |
Why this annotation
Overwhelmingly composed of nuclear-encoded mitochondrial F1F0 ATP synthase subunits (ATP5F1A/B/D/E, ATP5PO, ATP5PF, ATP5MC1/2/3, ATP5ME, ATP5MG), i.e. OXPHOS complex V, with accessory selenoproteins (SELENOW, SELENOK) and caveolar CAVIN1. High detection rate and uniform expression indicate an oxidative-metabolism/energy-production program supporting smooth muscle contractile work; it is a topological neighbor of the ambient module M82 because the smallest ATP5 transcripts are also high-abundance ambient species.
Genes
ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1E, ATP5MC1, ATP5MC2, ATP5MC3, ATP5ME, ATP5MG, ATP5PF, ATP5PO, CAVIN1, COPS9, MCRIP1, SELENOK, SELENOW, TRIR
Most correlated modules
- Ambient High-Expressors · correlation 0.88
- Baseline Maintenance Transcripts · correlation 0.88
- NO-cGMP Signaling · correlation 0.85
- HOX Positional Identity · correlation 0.80
- Mechanostress Early Response · correlation 0.77
- Mesenchymal lncRNA Activation · correlation 0.74
- Heat Shock Response · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.