Heat Shock Response
Gene co-expression module in Smooth muscle cells
| Category | Stress |
|---|---|
| Genes | 17 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 9 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes are the canonical cytosolic chaperone/heat-shock set (DNAJB1, HSPA1A/HSPA1B, HSPH1, DNAJA1, HSP90AA1, CHORDC1) together with immediate-early/stress transcription factors (FOSB, IRF1) and stress-associated lncRNAs (MIR22HG, SNHG12). This is the classic HSF1-driven heat-shock/dissociation stress response seen in enzymatically digested tissue; uniform expression across subsets argues against a cell-state-specific program. Its neighbors (M5 with CYR61/CTGF/NEAT1, M82 with ambient high-expressors) support a shared technical/stress axis rather than in vivo inflammation.
Genes
C12orf65, CEMIP2, CHORDC1, DNAJA1, DNAJB1, FOSB, H2AFX, HSP90AA1, HSPA1A, HSPA1B, HSPH1, IRF1, MIR22HG, SNHG12, TENT5C, THUMPD3-AS1, UBE2S
Most correlated modules
- Immediate Early Response · correlation 0.91
- NO-cGMP Signaling · correlation 0.84
- Mechanostress Early Response · correlation 0.83
- HOX Positional Identity · correlation 0.79
- Ambient High-Expressors · correlation 0.74
- Baseline Maintenance Transcripts · correlation 0.74
- ATP Synthase Complex · correlation 0.65
- Notch-TGFbeta Signaling · correlation 0.60
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.