HOX Positional Identity
Gene co-expression module in Smooth muscle cells
| Category | Development |
|---|---|
| Genes | 19 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 19 genes have a known function matching the annotation |
Why this annotation
Dominated by antisense/lncRNA transcripts of developmental transcription factor loci (HOXB-AS1, HOXB-AS3, TBX2-AS1, NR2F2-AS1) plus Notch effector NRARP, SEPT4 and MIR497HG — a positional-identity/regional patterning program typical of gut mesenchymal and smooth muscle cells retaining HOX code expression. Low mean expression and detection rate are consistent with nuclear, lowly expressed regulatory transcripts, not contamination. Distinct from its metabolic/stress neighbors; co-expression likely reflects a shared low-count nuclear transcript axis, but the gene identity is clearly developmental.
Genes
AC027644.3, AC092164.1, AL139246.5, FAM122A, FAM241A, GRAMD2B, HOXB-AS1, HOXB-AS3, HSPB11, LINC00982, MARCH2, MIR497HG, NR2F2-AS1, NRARP, PGGHG, PLA2G16, SEPT4, TBX2-AS1, TMEM131L
Most correlated modules
- NO-cGMP Signaling · correlation 0.95
- Baseline Maintenance Transcripts · correlation 0.89
- Ambient High-Expressors · correlation 0.89
- ATP Synthase Complex · correlation 0.80
- Heat Shock Response · correlation 0.79
- Mechanostress Early Response · correlation 0.76
- Notch-TGFbeta Signaling · correlation 0.72
- Pericyte Signature · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.