NO-cGMP Signaling
Gene co-expression module in Smooth muscle cells
| Category | Contractility |
|---|---|
| Genes | 11 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 3 of 11 genes have a known function matching the annotation |
Why this annotation
The functionally interpretable core is the soluble guanylate cyclase heterodimer GUCY1A1/GUCY1B1, the NO receptor that mediates smooth muscle relaxation, together with the scaffold SLC9A3R1 (NHERF1) and FOXO/starvation target DEPP1. The remainder (HIST1H4C, HOTAIRM1, uncharacterized AC-lncRNAs) are low-count nuclear transcripts that dilute the signal, so this is a partially mixed module whose SMC-relevant identity is NO–cGMP relaxation signalling. Neighbor M105 also contains MRVI1 (IRAG), the downstream cGMP effector, reinforcing a shared cGMP/relaxation axis in this neighborhood.
Genes
AC005884.1, AC068888.1, AL355974.2, DEPP1, GUCY1A1, GUCY1B1, HIST1H4C, HOTAIRM1, REX1BD, RTF2, SLC9A3R1
Most correlated modules
- HOX Positional Identity · correlation 0.95
- Baseline Maintenance Transcripts · correlation 0.91
- Ambient High-Expressors · correlation 0.90
- ATP Synthase Complex · correlation 0.85
- Heat Shock Response · correlation 0.84
- Mechanostress Early Response · correlation 0.80
- Immediate Early Response · correlation 0.70
- Pericyte Signature · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.